Integrating Multi-Omics to Address Unanswered Questions in Women’s Health: Insights into Endometriosis, Adenomyosis, and Beyond
Endometriosis and adenomyosis are debilitating gynecologic conditions that affect millions of women worldwide, yet their pathophysiology remains poorly understood, leading to delayed diagnoses and limited treatment options. Emerging evidence suggests that genetic, immune, and hormonal factors contribute to disease progression, while environmental exposures may further influence disease onset and severity. Despite their significant impact on reproductive health and quality of life, these conditions remain understudied, highlighting an urgent need for innovative research approaches. By leveraging integrated multi-omics analyses, including the microbiome, immunoproteomics, and metabolomics, we can unravel the complex interactions driving these diseases. A deeper understanding of these factors will pave the way for improved diagnostics, personalized therapeutic strategies, and targeted interventions, ultimately enhancing patient outcomes.
Short bio
Dr. Melissa Herbst-Kralovetz, a distinguished researcher from rural Arizona, has carved a significant niche in women’s health. A first-generation college student, she earned her bachelor’s degree from Colorado Mesa University and a doctorate in Experimental Pathology from the University of Texas Medical Branch. Since joining the University of Arizona College of Medicine-Phoenix in 2009, Dr. Herbst-Kralovetz has advanced to tenured professor in the departments of Basic Medical Sciences and Obstetrics and Gynecology. She directs both the Translational Women’s Health Research Program & Microbiome Initiative. Her innovative research delves into the microbiome and host-microbe interactions in the female reproductive tract, utilizing cutting-edge techniques such as 3-D bioreactor systems. Her work, funded by NIH and other esteemed foundations, aims to revolutionize women’s health outcomes. She has been honored with accolades such as the Phoenix Business Journal’s “40 under 40” award and the American Society of Reproductive Immunology’s “J. Christian Herr Award.” In addition to her academic roles, Dr. Herbst-Kralovetz is actively involved in FemTech and entrepreneurial endeavors, further advancing innovations in women’s health. A committed science communicator, she shares her insights through media engagements, including interviews, documentaries, and podcasts, ensuring her research reaches and benefits a wider audience.
Laboratory of the speaker
University of Arizona College of Medicine-Phoenix, Department of Basic Medical Sciences, Department of Obstetrics and Gynecology
Invited by
Zehra Esra Ilhan
