Vincent Sauveplane research interest is to decipher the rules driving gene expression in the gram-positive bacterium B. subtilis. His project will complete our knowledge of the biology of B. subtilis and will allow future rational designs of genetic circuits dedicated to biotechnological and synthetic biology applications. To summarize the project, we are interested in building and characterizing a library of synthetic genetic modules. These modules give us the ability to control transcription and translation of a gene of interest in the bacterium B. subtilis. The library of genetic sequences is used to control the production of a fluorescent protein. Its production level is analyzed during B. subtilis growth in various growth media (as a function of the medium richness).
Short curriculum vitae:
His professional career is made of scientific activities between academic and industrial laboratories (PhD co-supervised by Bayer BioScience and the CNRS, post doc at INRAE funded by the company Sofiprotéol and two years of experience as a researcher in the biotech company Eviagenics). His university studies have been performed at ENSAIA (National Engineering School of Agronomy and Food Industries) of Nancy, France, with a specialty in biotechnology. He then prepared a PhD at IBMP (Plant Molecular Biology Institute) in Strasbourg, France, where he studied lipid oxygenation processes in the model plant Arabidopsis thaliana. Following this experience, he switched toward microbial synthetic biology and biotechnology projects as a post-doc at INRAE and researcher at Eviagenics. Preceding his current position of assistant professor at AgroParisTech, these two experiences following his PhD were dedicated to metabolic engineering of the yeasts Y. lipolytica and S. cerevisiae to make them produce chemical synthons as well as metabolites for the pharmaceutical and food industries.
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